Abstract: Based on actual operation parameters of gas transmission pipeline, multilevel indexes system on comprehensive estimation for dispatch and operation of gas transmission pipeline is established. Weight of each index is calculated by improved analytic hierarchy process, which realizes complementary advantages in analytic hierarchy process with grey relational analysis. Based on multi-hierarchical grey relational analysis established, mathematical model of comprehensive estimation for dispatch and operation of gas transmission pipeline is constituted, and calculation steps are given. Comprehensive estimation software for dispatch and operation of gas transmission pipeline is configured based on VB & Access2003. Taking Sebei-Xining-Lanzhou Gas Transmission Pipeline as an example, comprehensive estimation on dispatch and operation program is made.