Abstract: In the light of the issues existed in aseismic design of pipeline sections laying over highly seismic region and moving fault zone in West-to-East Parallel Gas Transmission Pipeline Project, strain-based design method is introduced into the project and X80 large deflection steel pipes are adopted in crossing areas of moving fault zone. Definition, content, applicable scope and designprocess of strain-based design method is described and calculation model for strain-based design and design criterion are verified to ensure computing accuracy. Based on the design criterion and specific parameters of the pipeline, and combined with different aseismic techniques, design issues in pipeline laying over highly seismic region and moving fault zone are perfectly solved. It isconsidered that the rule of strain-based pipeline design can be used for instructing pipeline design and construction.