Abstract: A layering evaluation method integrated with orthogonal design, analytical hierarchy process, gray correlative analysis is put forward to assess design scenario for gas pipeline. This method can be used to determine optimal technical parameter combination to satisfy actual pipeline engineering based on orthogonal design and multiple indexes fuzzy comprehensive evaluation, then better scenario can be selected from preselective scenarios to meet the needs of technical parameter combination, and optimal design scenario can be obtained through comparison between the better scenarios contained 4 technical and economic index values. Cases analysis display that the layering evaluation method is available and feasible for realizing optimal selection in design of gas pipeline scenario.