Abstract: The authors consider that regulating and control of the oil transportation pipeline system in constant temperature is to control the pressure of pipeline because the pressure of pipeline is a key factor to influence the safe operation of pipeline. Start/stop of oil pump, revolution regulation of frequency-variable pump and the opening of regulating valve are effective measures to ensure safety operation of pipeline systems, especially for the control point and key point, with continuity and integrity. It is pointed out that taking several technical measures such as relief valve, pressure switches, leading protection and ESD procedure can effectively ensure the safety of pipeline system and enhance safety coefficients in pipeline operation.