Abstract: This paper introduces the calculation equations of hydraulic frictional resistance coefficient of 6 kinds of gas liquid phases given by present literatures, develops the stratified calculation program on the basis of bio-liquid model and compares the calculation results of hydraulic friction resistance coefficient to experimental data obtained from the multiphase liquid device. Different equations of hydraulic frictional resistance coefficient lead to different results and equation of Andritsos & Hanritty give the result that approaches experiment data.