Abstract: This paper introduces the reconfiguration adjustment of hardware and software optimization of SCADA system to solve the problem of parameters required on sampling frequency in leakage detection of oil pipeline with negative pressure wave method, the effective measures to be taken to reduce interfere to improve the sensitivity and reliability in oil leakage, also, the design thought and function of application software. The main technical indexes of detection and location of oil leakage of the system are identified by the site experimental results.