Abstract: The head pressure of Jidong gathering and transportation pipeline is very high because of the hypsography of Shi 'nan Oilfiled, as a result the gas and liquid of some metering and distribution stations can not flow to the gathering and transportation system. Therefore, the pressure drops of the hypsographic subsection pipeline lines are measured and predicted by the calculation models of gas-liquid multiphase flow in common use. The results show that the pressure predicted by the three-phase flow relations for the calculation of subsection pipelines is closest to the measured, and its error is about five percent to thirty percent and the predicted pressure is more conservative. The pump model for oil-gas-water multiphase flow is selected according to the predicted results, and the pump station and its corresponding control system are constructed nearby the start point of Jidong gathering and transportation pipeline. The application of the pressure increasing technique for oil-gas-water multiphase flow in Jidong Oilfield not only effectively solves the difficult problems of the Oilfield's multiphase flow and improve its social and economic benefits, but also accumulates some helpful experiences on the technical engineering application.